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Therefore, to further dissociate the effects of GSH and NRF2 on lipid abundance and assess if NRF2 activation alone mimics the effects of liver-specific Gclc deletion, we treated Gclc WT mice with CDDO-methyl (CDDO-Me), a form of bardoxolone with increased bioavailability

It was also more effective than conventional Western medicine alone in overall clinical symptom improvement and shortened the duration of jaundice by approximately 6 days ( TABLE 3 Summary of key clinical trials on glycyrrhizin preparations in liver disease

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